Here is our prediction for CAPRI Target 10, the trimeric form of the Tick-Borne Encephalitis Viral Protein. This posed a new problem to protein-protein docking, as 3 individual monomers needed to be modelled, as opposed to the traditional problem where only 2 monomers are used.

We show our prediction (ranked 12th for CAPRI, but modification of our algorithm now ranks this complex first) superposed with the native form of the trimer.

The TBEV complex actually forms as a dimer, then dissociates to form a trimer. The dimeric form had been previously crystallized and served as the "unbound" protein. The trimeric form is shown in red, blue, and pink. Our prediction is shown in yellow, green, and tan. Note that there are significant conformational changes upon binding (as evidenced by the difference between the red and yellow monomers).